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Immunomedics announces Pivotal examine of Sacituzumab Govitecan in sufferers With in the neighborhood superior or Metastatic Urothelial melanoma | real Questions and Pass4sure dumps

MORRIS PLAINS, N.J., June 01, 2018 (GLOBE NEWSWIRE) -- Immunomedics, Inc. (IMMU) (“Immunomedics” or the “company”), a number one biopharmaceutical company within the district of antibody-drug conjugates (ADC), today announced that the company plans to initiate a section 2 pivotal TROPHY U-01 examine of sacituzumab govitecan, the company’s lead investigational ADC, as a sole agent in patients with in the community advanced or metastatic urothelial cancer (mUC) who absorb relapsed after a platinum-primarily based regimen and/or immune checkpoint inhibitor (CPI) remedy.

“Urothelial cancer sufferers who absorb relapsed after, or are refractory to platinum chemotherapy and the lately accredited CPI remedies, absorb a broad unmet necessity with few attainable treatment alternatives,” remarked Dr. Rob Iannone, Head of R&D and Chief clinical Officer of Immunomedics. “we are completely satisfied with the FDA suggestions on anatomize design and protocol development, which is aligned with the enterprise’s level to bring this talents vital treatment alternative to patients expeditiously.”

The facet 2 pivotal examine, which is anticipated to breathe activated next week, will breathe a sole arm, foreign, multicenter study so one can combine about 100 mUC patients who absorb bought prior platinum-primarily based and CPI treatment. The primary endpoint might breathe ordinary response price, with length of response, progression-free survival, and ordinary survival serving as secondary endpoints. Response assessments can breathe in response to RECIST 1.1 and total patients might breathe centrally reviewed. moreover, the study will additionally combine an extra and sunder cohort of patients who're cisplatin ineligible and absorb received prior CPI treatment to respect defense and efficacy in an previous medication setting. 

About Sacituzumab GovitecanSacituzumab govitecan, their most superior product candidate, is a novel, first-in-class antibody-drug conjugate (ADC). it's at the minute below assessment via the U.S. food and Drug Administration for accelerated approval as a medicine of sufferers with metastatic triple-poor breast cancer who previously received at least two prior remedies for metastatic disorder. If authorized, sacituzumab govitecan often is the first and best ADC permitted for the treatment of metastatic triple poverty-stricken breast cancer.

About ImmunomedicsImmunomedics is a clinical-stage biopharmaceutical industry constructing monoclonal antibody-based mostly items for the centered treatment of melanoma and other captious illnesses. Immunomedics’ corporate goal is to become a totally-built-in biopharmaceutical enterprise and a pacesetter within the box of antibody-drug conjugates. For additional info on the enterprise, tickle visit its site at The suggestions on its web site does not, besides the fact that children, kindhearted a fragment of this press liberate.

Cautionary word involving ahead-searching statementsThis liberate, in addition to frail counsel, may additionally hold forward-searching statements made pursuant to the deepest Securities Litigation Reform Act of 1995. Such statements, including statements involving medical trials (including the funding therefor, anticipated patient enrollment, trial consequences, timing or linked fees), regulatory purposes and connected timelines, together with the submitting and approval timelines for BLAs and BLA dietary supplements, out-licensing arrangements, forecasts of future working effects, expertise collaborations, capital elevating actions, and the timing for bringing any product candidate to market, hold huge dangers and uncertainties and genuine consequences might fluctuate materially from these expressed or implied herein. components that may trigger such alterations consist of, but are not restricted to, the company’s dependence on enterprise collaborations or availability of required financing from capital markets, or other sources on applicable terms, if at all, with the intent to extra enhance their products and finance their operations, current product development (including scientific trials influence and regulatory necessities/moves), the possibility that they or any of their collaborators could breathe unable to at ease regulatory approval of and market their drug candidates, dangers associated with the result of pending litigation and competitive hazards to marketed items, and the business’s faculty to repay its outstanding indebtedness, if and when required, as well as the dangers discussed within the enterprise’s filings with the Securities and change commission. The enterprise is not below any responsibility, and the enterprise expressly disclaims any duty, to update or alter any ahead-searching statements, whether on account of current counsel, future activities or in any other case. 

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BiolineRx Has broad Upside In 2018 | real Questions and Pass4sure dumps

Editor's breathe aware: in the hunt for Alpha is arrogant to welcome Jeff Hetmansperger as a brand current contributor. it's convenient to revolve into a in quest of Alpha contributor and win money to your example investment ideas. energetic contributors additionally score free access to SA seasoned. click here to find out more »

BiolineRx (NASDAQ:BLRX) is a clinical-stage bio-pharmaceutical enterprise working primarily as company development entity seeking to determine, in­-license, and better promising drug candidates generated via research corporations, universities, and wee biotech start­americain Israel and globally. These drug candidates are do via a complete screening manner to construct positive their technical and scientific feasibility, IP protection, and their industry knowledge. through this technique, the enterprise has developed a broad and wealthy pipeline in different therapeutic areas, primarily in oncology and immunology.

I trust BiolineRx is at a broad inflection point and its valuation is set to change in a massive approach in 2018. this text will focus on the the reason why i am so confident and bullish concerning the present and the future of this company. under are one of the crucial the explanation why I accept as loyal with BiloineRx is at present grossly undervalued:

  • The company is conducting 8 clinical trails the usage of its potentially blockbuster drug candidate BL-8040 in a number of liquid and solid tumor signals, both as a monotherapy and in combination with other oncology medication,
  • BL-8040 continues to deliver notable consequences as viewed by pass of papers introduced eventual week at ASCO Gastrointestinal Cancers Symposium and at this week's ASCO-SITC Immunology.
  • essentially the most advanced BL-8040 program is a fragment clinical trial introduced on December 21, 2017 assessing BL-8040 for the mobilization of hematopoietic arise cells for autologous transplantation in varied myeloma patients
  • New oncology asset AGI-134 shoewed staggering outcomes in preclinical melanoma reports at ASCO-SITC Immnunology.
  • company is not off course to initiate fragment 1/2A strong-tumor drug candidate AGI-134 clinical trials in 1H 2018,
  • BiolineRx has a few partnerships and collaborations with major world pharma companies,
  • The industry is at present running 10 BL-8040 medical trials in solid and liquid tumors, by myself and in composite trials with immunotherapy brokers Merck's KEYTRUDA, Genentech's Tecentriq, and others.
  • The company has a big number of different drug candidates with confederate Novartis together with those for NASH, diabetes, and optical purposes poised to enter the hospital in 2018
  • certainly one of its products is in early levels of commercialization (licensed to Perrigo),
  • The industry is funded to 2020 with $60M money and no LT debt,
  • BiolineRx enjoys robust institutional aid,
  • 4 analysts ahve a buy score on the inventory with a consensus price target of $3.25/share. this means an almost 300% upside from state-of-the-art $1.1/share closing expense.
  • For a corporation with a market cap of cramped over $100M, BioLineRx has essential collaborations with main pharma companies like Novartis (NYSE:NVS), Merck (NYSE:MRK), and Genentech/Roche (OTCQX:RHHBY). The strategic collaboration with Novartis is for the co­-building of selected Israeli­ sourced novel drug candidates. With Merck, the enterprise is operating a section 2 gawk at in pancreatic melanoma the utilize of the combination of its lead compound BL­8040, and Merck's KEYTRUDA. throughout the collaboration settlement with Genentech, the industry is investigating the aggregate of BL­8040 and Genentech's atezolizumab in distinctive strong tumor signals and AML.

    The Novartis collaboration became introduced on December 16, 2014. during the multi-year partnership, Novartis will absorb entry to the optimum drug candidates recognized through BiolineRx in the enviornment of immunology. Novartis invested an initial $10 million by means of acquiring 5 million BLRX shares in a personal transaction at $2.00 a share.

    as soon as a undertaking is chosen, Novartis pay BioLineRx an option fee of $5 million and fund half the final construction expenses in the sort of an extra equity funding within the business. An instance of this collaboration is the settlement announced on September 23, 2016, whereby BioLineRx signed an exclusive worldwide settlement to in-license liver candidate BL-1220 to deal with end-stage liver sickness and stipulations resulting in liver failure akin to NASH.

    related to this deal, Philip Serlin, BiolineRx CEO commented:

    “In August this 12 months, they in-licensed the first compound beneath their multi-12 months strategic partnership with Novartis, a novel drug candidate for controlling liver fibrosis via modulation of the immune system.”

    “both of those initiatives hale their strategic headquarters of attention on the immunology house. They continue to toil intently with Novartis to determine cutting-area, novel healing procedures and they hope to bring extra promising tasks to the collaboration with the aid of the conclusion of the 12 months," he introduced.

    i'll deliver more colour on the Novartis, Genentech, and Merck collaborations later in this article.

    January 2018 A assiduous Month For BLRX

    January 2018 turned into the busiest month in business's history related to participation in conferences (Biotech argue off and JPM health conference) and proposing medical records at ASCO Gastrointestinal Cancers Symposium and ASCO_SITC Immuno-Oncology Symposium. These 4 conferences absorb been held in San Francisco, CA.

    right here is a summary for essentially the most notable scientific records presented through BiolineRX in January 2018:

    At ASCO Gastro, the enterprise presented partial effects from the monotherapy component of BL-8040's fragment 2a fight study (with Merck's KEYTRUDA) showing a major infiltration of T cells into the tumor in patients with metastatic pancreatic cancer. The consequences showed as much as a 15-fold enhance in CD3+ T cells, and up to a 2-fold enhance in CD8+ T cells, in the tumor micro-environment (TME) of 43% of the patients, after 5 days of BL-8040 monotherapy. The partial outcomes showed that BL-8040 became secure and smartly-tolerated.

    Lead investigator, world-well-known oncology knowledgeable Dr. Manuel Hidalgo commented:

    "this is the first time they behold outcomes of BL-8040 in pancreatic melanoma patients. The effects of the monotherapy fragment of the fight trial are extraordinarily encouraging as they ascertain the mechanism of motion of BL-8040 in this complex-to-treat patient population, leading to T-cellphone infiltration into the tumor after simplest 5 days of monotherapy with BL-8040. These effects befriend the rationale for combining BL-8040 with checkpoint inhibitors, and i am keen for the topline effects of the fight gawk at anticipated later this year."

    Philip Serlin, Chief government Officer of BioLineRx brought,

    "The results parade that BL-8040 induces robust infiltration of anti-tumor T cells into liver metastases in nearly half of the pancreatic cancer sufferers who underwent a biopsy, simply reworking these tumors from immunologically 'cold' to 'hot', which is viewed as key in the goal of improving the responsiveness of patients with pancreatic melanoma to front-line immunotherapy."

    T-cellphone infiltration might breathe a key to enrich response to therapy. this can flip the tumor from bloodless to sizzling, and hence render it fine to remedy.

    here slither is BiolineRx depiction on how BL-8040 is envisioned to toil within the tumor micro-ambiance (TME), which changed into validated with this data, and why Merck and Genentech are doing clinical trials in composite with their blockbuster immunotherapy agents KEYTRDUDA and Tecentriq respectively (from December 2017 company presentation):

    The enterprise introduced the identical records at ASCO-SITC the following week.

    The subsequent BL-8040 presentation entitled, "CXCR4 antagonist (BL-8040) to enhance antitumor consequences by pass of expanding tumor infiltration of antigen-certain effector T-cells. (abstract 73)," turned into delivered at ASCO-SITC Immuno-Oncology January 25 -27, 2018.

    The records further validated the MOA, depicted in the slither above, displaying remedy with BL-8040, in aggregate with a melanoma vaccine that primes the immune device towards the tumor, vastly improved the anti-tumor response in comparison to either agent administered by myself. The outcomes confirmed that BL-8040 significantly raises the abundance of tumor-certain T-cells within the TME.

    Lead investigator, oncology professor Dr. Samir Khleif, had this to proclaim about these outcomes:

    "i'm highly inspired by pass of the statistics generated in this preclinical study, which extra demonstrates the therapeutic capabilities of BL-8040. The effects provide extra proof that BL-8040 promotes the infiltration of cytotoxic T-cells into tumors, which is seen as a key level to enrich responsiveness to checkpoint remedy. I appear ahead to seeing the consequences from the medical reports by which BL-8040 is being combined with checkpoint blockade (KEYTRUDA and Tecentriq)."

    CEO Philip Serlin added,

    "we've shown in a lot of preclinical and clinical reports that BL-8040 has quite a few anti-tumor outcomes, including direct and indirect outcomes, influencing T-phone vicinity and undertaking as well as tumor mobile survival. The outcomes of the existing study argue that BL-8040 enhances anti-tumor immune response via expanding the variety of anti-tumor T-cells within the TME. These consequences besides argue that BL-8040, a CXCR4 antagonist, is a promising immune-modulatory agent with powerful anti-tumor effects, and they remain not off course with their eight ongoing medical trials for this product in numerous signs, each in blood cancers as well as in solid tumors."

    The third facts presentation in January involved current oncology asset AGI-134. The presentation entitled: "Intratumoral administration of the alpha-Gal glycolipid AGI-134 to result in tumor regression in a mouse mannequin of melanoma. (summary 68)." become introduced at ASCO-SITC Immuno-Oncology January 25 - 27, 2018.

    These effects absorb been nothing wanting outstanding. records from two mouse melanoma fashions confirmed intratumorally injected AGI-134 brought about complete tumor regression in 50% and sixty seven% of mice, respectively. treatment with AGI-134 additionally showed a positive repercussion on survival compared to control.

    CEO Philip Serlin commented:

    "previous reviews absorb established that intratumoral administration of AGI-134 induces a systemic anti-tumor response that protects mice from the structure of far-off tumors. These current reports now betray direct regression of established fundamental tumors after injection with AGI-134, and that this regression is associated with activation of the hereditary immune equipment."

    "These compelling pre-medical data usher investigating this fashion in a fragment 1/2a study, and we're excited and on track to commence a primary-in-man anatomize with this promising novel oncology asset in sufferers with solid tumors within the first half of 2018."

    The information introduced at ASCO_SITC validates AGI-134's MOA which, after injection right into a tumor, generates a pro-inflammatory tumor microenvironment that pulls and prompts other immune cells, subsequently resulting in adaptive anti-tumor immunity, as a consequence killing the injected as neatly as the far-off metastasized tumors. The slither beneath suggests the conceptual AGI-134 MOA:

    Melanoma is essentially the most sedate category of dermis melanoma because it can spread or metastasize to other tissues and organs within the body. Metastatic melanoma regularly spreads to the tissue beneath the skin, lymph nodes, lungs, liver and brain. coincident advances in treatment absorb tremendously prolonged survival in some patients with metastatic melanoma. youngsters, current treatments are nonetheless urgently crucial to befriend more sufferers control their disease. it is envisioned that AGI-134 may besides breathe advantageous as a monotherapy and in combination with permitted immunotherapy drugs.

    extra On BL-8040

    BL­8040, as a powerful CXCR4 antagonist, has the capabilities to goal and Kill numerous solid ­tumor melanoma cells as well as hematological melanoma cells. BL­8040 has shown to induce mobilization of malignant cells into the peripheral blood from their hiding locations like the bone marrow, which gives coverage from chemotherapeutic brokers. previous clinical studies absorb proven that BL­8040 is effective, each lonesome and in composite with different cancer medicine, in cutting back bone marrow metastasis of lymphoma cells and stimulating apoptosis, or lymphoma mobile death.

    BL-8040 medical records shared through the enterprise on December four, 2017, showed that BL-8040 in its facet 2a trial for the remedy of relapsed or refractory acute myeloid leukemia in aggregate with excessive-Dose Cytarabine (HiDAC), significantly more suitable typical survival, compared with frail records of HiDAC mono-remedy. The composite of BL-8040 with HiDAC become well tolerated displaying a response expense of 38%. Median medium survival become 11.1 months, the estimated one-yr survival price become 37.5% and the estimated two-yr survival expense become 28.5%. This compares favorably to ancient facts for sufferers treated with HiDAC monotherapy displaying overall survival of handiest 6.1 months. moreover, the subset of sufferers exhibiting a response showed extended ordinary survival, with estimated one-12 months and two-yr survival prices of 60%.

    After these results had been out, Oppenheimer reiterated its Outperform rating at $3/share fee goal on the stock. Analyst stamp Breidenbach commented, "We trust BL-8040 might generate adequate earnings revenues as a arise cell mobilizer to gawk the company cash flow wonderful by 2021. additionally, the drug may additionally prove to breathe an exceptional chemo-sensitizer for sufferers with leukemia, and the next 12-18 months are replete with catalysts, together with an meantime readout from a randomized AML examine."

    also on December four, 2017, Maxim neighborhood set a $three.00 goal fee on BiolineRx and gave the company a buy score in a research report.

    Following the December 21, 2017 announcement that the company initiated its section 3 medical trial, GENESIS, assessing BL-8040 for the mobilization of hematopoietic arise cells for autologous transplantation in diverse myeloma patients, HC Wainwright set a $4.00 target cost on BiolineRx on a analysis note issued on December 25, 2017. The brokerage currently has a buy ranking on the inventory.

    GENESIS will examine the composite of BL-8040 and granulocyte colony-stimulating aspect (G-CSF) to placebo plus G-CSF in about a hundred and eighty topics. The fundamental endpoint will breathe the percentage of sufferers who mobilize a prescribed minimum number of CD34+ cells with up the two apheresis periods after a sole administration of BL-8040 and G-CSF.

    a different essential recent development the industry announced on October 18, 2017, the initiation of a composite trial of BL-8040 and atezolizumab (Genentech's Tecentriq) in patients with gastric cancers. this is a fragment of the initiative for the structure of novel cancer immunotherapy combinations between the business's BL-8040 powerful CXCR4 antagonist and Genentech's multi-billion dollar anti-PDL1 melanoma immunotherapy agent addressing a number of strong tumors including pancreatic, gastric and non-small cell lung melanoma.

    right here slither depicts the medical arrangement to execute this essential clinical trial:

    besides with Tecentriq, the company announced on September 26, 2017, the initiation of section 1b/2 trial, named fight, assessing the aggregate of BL-8040 and atezolizumab for the preservation medicine of sufferers with intermediate and high-chance acute myeloid leukemia who absorb accomplished a complete response following induction and consolidation remedy.

    The trial will token up as much as 60 patients. The fundamental endpoint is relapse-free survival. The result of the aggregate remedy on minimal residual sickness, multiple immunological parameters and advantage biomarkers will besides breathe evaluated.

    The section 2 partial consequences for the combat scientific trials stated at ASCO Gastro 2018, and discussed above, are for the BL-8040 monotherapy ingredient of the reviews earlier than the introduction of KEYTRUDA (factor 5 in right here slide). This step is essential to argue pancreatic cancer cells by using priming the micro-tumor atmosphere in order that KEYTRUDA can evaporate to toil and Kill the tumors extra without difficulty:

    plenary fragment 2 statistics for these trials can breathe pronounced in 2H 2018.

    greater On AGI-134

    BioLineRx (BLRX) introduced on March 23, 2017, the acquisition of Agalimmune Ltd., a private UK-based mostly enterprise with an ingenious, anti-melanoma immunotherapy platform having AGI-134 as its lead drug candidate. BioLineRx reportedly paid $6M upfront, with $3M in cash and the the repose in BLRX shares.

    within the acquisition announcement, BioLineRx CEO Serlin commented:

    "Agalimmune's lead asset, AGI-134, harnesses naturally happening, pre-latest antibodies to elicit a tumor-specific immune response it really is wonderful to the treated individual and gives a frequent, small-molecule fashion to customized immunotherapy. we're enthusiastic to embrace into their pipeline this promising close-scientific asset, which noticeably strengthens their situation within the immuno-oncology house."

    In layman's phrases, Agalimmune's technology works by harnessing the physique's personal immune gadget to Kill solid tumors. The drug is injected right into a goal tumor, and thru a series of movements, it kills the local tumor. once particles from the killed tumor enters the blood circulate, the body's immune gadget generates and programs T-cells, in keeping with the chemical structure of the killed tumor, and attacks and kills total of the other tumors that resulted via metastasis. This consequences in a personalised remedy, potentially leading to stronger responses over other existing strong-tumor technologies. The mechanism of motion of AGI-134 reminds me of Idera's (IDRA) lead drug candidate for strong tumors, IMO-2125, the utilize of a wholly distinctive method. With a tremendously smaller pipeline, Idera's market cap become 4 instances better than BiolineRX earlier than the January 22, 2018 announcement that it had merger with BioCryst Pharma. i will breathe able to talk about the disconnect between BilioneRx low valuation and its huge upside competencies.

    AGI-134, as a wee molecule that can generate systemic T mobile responses towards the patient's own neoantigens in situ and with a benign safety profile, it can breathe a fantastic candidate to utilize in aggregate with immunotherapies similar to checkpoint inhibitors.

    AGI-134 has efficiently completed numerous pre-medical studies. In these stories, AGI-134 demonstrated positive destruction of fundamental and secondary tumors and supplied strong insurance policy in opposition t the formation of current tumors in melanoma models with a sole dose most effective. The drug has besides demonstrated a synergistic repercussion when combined with checkpoint inhibitors in extra pre-clinical reports. this is another reason BLRX's management is so bullish in regards to the drug's prospects when you respect that it would proffer the chance to augment the price and duration of responses in several cancer forms with the aid of working at the side of checkpoint inhibitors.

    as a result of its novel mechanism of action, AGI-134 is a opening current frontier within the fight towards melanoma the situation presently it breathe the most efficient player. Being first, and being successful in oncology is rewarded accordingly in due time.


    The December 2017 company Presentation shows the popularity of the latest pipeline

    As can besides breathe seen in the slither above, besides oncology and immunotherapy collaborations with Genentech and Merck, the industry is working with a few drug candidates within the enviornment of immunology, essentially with Novartis. The slither additionally shows that that its BL-5010 dermatological drug has reached industry stage. On April 4, 2016, the industry announced that its confederate Omega Pharma (now a fragment of Perrigo) has received CE stamp approval for BL­5010 as a novel OTC medication for the non­surgical removing of dermis lesions. The industry expects to document significant revenues as the advertising plans for BL5010 are being done.

    most primary Upcoming medical Milestones

    right here slither suggests principal milestones that traders may still hope in 2018. commemorate that the shows proven on table 1 aren't protected within the slither as a result of they are simplest meantime facts, however even so very essential within the manner of structure the price of BL-8040 and AGI-134 as competencies blockbuster drug candidates addressing a broad sweep of oncology indications.

    Insider ownership

    investors will notice in daunt that insiders don't personal any company shares. The motive is awfully standard, they aren't allowed to finish it as a result of BiloineRx is primarily a "business structure firm" working three hundred and sixty five days a year on wee to colossal offers to expand the pipeline, to enter into gigantic pharma collaborations, acquire or dispose property, etc. buying shares with the insider advantage of a huge efficient structure would constitute "Insider trading." The corporate Governance files detail these guidelines to your assistance

    Institutional possession

    For a inventory buying and selling near to $1/share, BiolineRx has very robust institutional aid with a current 40% ownership (up from 15% two quarters in the past). Bvf Inc, the biggest holder, extended its stake in Biolinerx Ltd (BLRX) through forty eight.fifty five% from 17.5M to 26M shares in accordance with its latest 2017Q3 regulatory filing with the SEC. Novartis owns 5.4M shares of BLRX inventory. Deutsche bank Ag, Morgan Stanley, Renaissance technologies, and other gigantic traders were including in fresh quarters. A coincident Seekingalpha blog publish by contributor Hawkinvest entitled: "BioLine RX: This $1 Biotech stock offers a superb possibility To Reward Ratio And Upside Catalysts For 2018," gives a greater wide dialogue of this, and different crucial themes involving this security.

    hazards and uncertainties

    as with every biotech in the medical-construction stage, there are a yoke of expertise hazards that should still breathe considered:

  • Failure of clinical trials.
  • enormous collaborators opting out of existing agreements for a number of explanations like restructuring, buyout, disappointing medical results, and so on.
  • extreme dilution is expenses score out of control because of mismanagement and absence of focal point.
  • Collaborator exit could occasions and boost money singe that might trigger the enterprise to are seeking for equity financing as a result diluting shareholders.
  • loss of key faculty to the competition.
  • Acts of terrorism, war, or herbal mess ups.
  • Conclusions

    The industry has been making huge growth due to the fact Philip Serlin changed into named CEO of BiolineRx in August 2016. This progress accelerated in 2017, and the momentum is carrying into 2018 positioning the company for a considerable raise in valuation. Any biotech having pronounced the robust medical consequences of the ultimate two weeks on properly of what turned into finished in 2017 could absorb doubled or tripled in valuation. Many latest BLRX owners are disappointed in regards to the stock performance to date, and many might absorb left early in search for greener pastures. but I respect there are causes for it, and as soon as the sentiment adjustments, BLRX will attain current highs. listed here are some of these explanations:

  • BiolineRx is based in Israel. unprejudiced or unfair there's a undeniable stigma linked to biotechs based mostly outdoor the U.S. and in Israel in specific. Analysts after they apportion a cost goal they lop price the "based in Israel" factor to situation within the identical level playing field with US-based groups. however this would not count number to tremendous pharma who're normally trying to find the subsequent block-buster drug globally. Many US-based biotechs are valued again and again greater than BLRX having significantly smaller pipeline and less lengthy-time epoch capabilities.
  • As any biotech, BilioneRX had its disasters and because of this the market has a "show-me" angle with the stock. Many investors finish not even recognize that CEO Serlin is comparatively current and hence he can't breathe blamed for previous issues. definitely, CEO Serling is US-born finance guy and very eloquent in comparison (watch video) to different Israel CEOs who absorb rigor offering facts in regards to the industry at traders' meetings and convention calls.
  • BiolineRx has no insider purchasing. As defined before, the character of its company precludes insider purchasing to steer transparent of "insider trade" instances as a result of they are in company development 24/7.
  • In October 2017, the enterprise entered into an ATM condense with BTIG to promote up to $30 million of industry shares at the discretion of the business. I believe the company has been selling inventory as quantity has extended significantly on the grounds that mid November. In its upcoming fiscal liberate the industry will seemingly file a lots larger cash steadiness than the expected $50M with ATM sales. here's decent and bad, first rate since the company's runway gets extended drastically, and unsafe since it keeps the pps lower than it might with out the overhang. Retail traders might believe "why sell now, finish not they suppose the enterprise has skills"? however biotech CEOs worship the security of a powerful steadiness sheet if you want to focus on execution. furthermore, it is additionally likely that the industry has its eyes in acquiring an asset for cents on the dollar, eventually creating more cost as within the case of AGI-134.
  • With the company making colossal growth on its high-abilities pipeline, having a powerful stability sheet, and with the subsequent 12-18 months replete with potentially potent catalysts, the inventory will no longer remain this undervalued perpetually. Analyst concur with this statement as their rate ambitions of $3 to $four/share suggests very giant upside competencies. The expertise draw back possibility is low considering that the company is buying and selling simplest 30c above money value.

    for my part, I finish not know of any sub-$5 biotech and sub $500M market cap that proffer a more diverse and promising pipeline portfolio than BioLineRx offers. I've mentioned Idera (NASDAQ: IDRA) as an instance, however i will besides feel of AVEO Pharma (NASDAQ: AVEO), Infinity Pharma (NASDAQ: INFI) and a lot of different biotechs having a fraction of BiolineRX's pipeline with market caps three - 5 instances higher. additionally, there are no sub-$500M market cap biotechs which absorb partnerships and collaboration with three of the biggest pharma companies on this planet.

    The relaxation of 2018 is besides loaded with foremost catalysts like topline fragment 2 pancreatic cancer with MRK's KEYTRUDA, effects of BL-8040 trials with Genentech's Tecentriq, a few medical outcomes for liquid cancers, initiation of AGI-134 in-human trials, and advancing several immunology courses with accomplice Novartis (NASH, diabetes, ophthalmology, and so forth.).

    The massive talents packed with BiolineRX is being mentioned via primary investors like BVF partners having invested just about $30M bucks in BioLineRx after an instantaneous $9.6 million investment at $1.13 per unit, for yardstick shares and warrants with 4-yr phrases. because warrants are priced at $2 and $4/share means that this universal funding enterprise believes this inventory will eventually trade above $2 and even $4 per share.

    BLRX, as any stock available in the market, and specially since it can breathe a very volatile biotech stock, it may besides breathe very unsafe regardless of its advantage. investors may still total the time assessment in ingredient the entire dangers and uncertainties as listed in the business's filings with the SEC.

    Disclosure: i am/we're long BLRX.

    I wrote this text myself, and it expresses my own opinions. i'm not receiving compensation for it (apart from from in search of Alpha). I haven't any industry relationship with any company whose inventory is mentioned listed here.

    Editor's word: this article covers one or extra stocks trading at under $1 per share and/or with less than a $one hundred million market cap. tickle breathe awake about the hazards linked to these shares.

    Bristol-Myers Squibb Receives efficient CHMP sentiment within the European Union for Opdivo (nivolumab) for the medicine of advanced Melanoma in each First-Line and up to now ... | real Questions and Pass4sure dumps

    PRINCETON, N.J.--(company WIRE)--Bristol-Myers Squibb enterprise (NYSE:BMY) these days introduced that the Committee for Medicinal products for Human utilize (CHMP) of the european medicines company (EMA) has adopted a benign sentiment recommending that Opdivo (nivolumab), a PD-1 immune checkpoint inhibitor, breathe granted acclaim for utilize in both first-line and prior to now treated patients with advanced (unresectable or metastatic) melanoma. here is the first superb sentiment given by the CHMP for a PD-1 immune checkpoint inhibitor, and it'll now breathe reviewed by the eu commission, which has the authority to ratify drugs for the european Union (european).

    The EMA granted Bristol-Myers Squibb accelerated assessment of Opdivo in response to existing laws that fulfills its guidance about “medicinal items of fundamental hobby from the aspect of view of public fitness and in selected from the view ingredient of therapeutic innovation.”

    “we are blissful with nowadays’s CHMP superb opinion, as it is a step nearer to us bringing this captious medication for these superior melanoma sufferers in Europe in necessity of current alternate options,” spoke of Michael Giordano, senior vice chairman, Head of building, Oncology. “Our imaginative and prescient is to radically change how they approach cancer – from clinical practice to improved affected person effects. They continue to extend the breadth and depth of their immuno-oncology portfolio across the continuum of melanoma and numerous other cancers, to give more sufferers with the scholarship possibility for lengthy-time epoch survival.”

    superb sentiment in line with CheckMate -066, -037

    The CHMP advantageous sentiment is in response to facts from two fragment III stories (CheckMate -066 and -037), demonstrating the efficacy and safety of Opdivo in advanced melanoma sufferers with captious unmet needs. CheckMate -066, a fragment III randomized double-blind analyze, comparing Opdivo to the chemotherapy dacarbazine (DTIC) in patients with medication-naïve superior melanoma, is the primary facet III trial of an investigational PD-1 immune checkpoint inhibitor to exhibit an medium survival improvement in advanced melanoma, as well as a stronger purpose response fee. A 2nd study, CheckMate -037, is a fragment III randomized, controlled open-label gawk at of Opdivo versus investigator’s alternative chemotherapy in sufferers with advanced melanoma who were previously handled with Yervoy (ipilimumab), which showed development in objective response rates. These records are supported by means of a facet Ib gawk at (examine -003) in relapsed advanced or metastatic melanoma, which demonstrated the primary characterization of Opdivo improvement/possibility in superior melanoma. There was consistent Opdivo dosing of 3 mg/kg each two weeks across total three trials.

    About Opdivo

    Bristol-Myers Squibb has a vast, global structure software to examine Opdivo in diverse tumor forms such as greater than 50 trials – as monotherapy or in aggregate with different cures – wherein more than 7,000 patients had been enrolled global.

    Opdivo became the primary PD-1 immune checkpoint inhibitor to acquire regulatory approval anywhere in the world on July four, 2014 when Ono Pharmaceutical Co. announced that it got manufacturing and advertising approval in Japan for the remedy of sufferers with unresectable melanoma. within the U.S., the U.S. food and Drug Administration (FDA) granted its first popularity of Opdivo for the medication of patients with unresectable or metastatic melanoma and sickness development following Yervoy (ipilimumab) and, if BRAF V600 mutation tremendous, a BRAF inhibitor. On March 5, 2015, Opdivo lately obtained its 2nd FDA popularity of the medicine of sufferers with metastatic squamous non-small phone lung melanoma (NSCLC) with progression on or after platinum-primarily based chemotherapy.

    About advanced Melanoma

    Melanoma is a sort of skin cancer characterised through the uncontrolled augment of pigment-producing cells (melanocytes) institute within the epidermis. Metastatic melanoma is the deadliest sort of the disease, and happens when cancer spreads beyond the surface of the epidermis to the other organs, such as the lymph nodes, lungs, reason or other areas of the body. The incidence of melanoma has been expanding for at least 30 years. In 2012, an estimated 232,130 melanoma cases were clinically determined globally. Melanoma is commonly curable when treated in its early levels. however, in its late ranges, the general survival rate has traditionally been simply six months with a one-12 months mortality fee of 75%, making it one of the vital aggressive sorts of melanoma.

    Immuno-Oncology at Bristol-Myers Squibb

    surgery, radiation, cytotoxic or targeted treatment options absorb represented the mainstay of cancer medication over the eventual several decades, but lengthy-time epoch survival and a qualified excellent of life absorb remained elusive for many sufferers with advanced ailment.

    To address this unmet medical want, Bristol-Myers Squibb is main research in an resourceful box of melanoma analysis and treatment called immuno-oncology, which contains agents whose primary mechanism is to toil without retard with the physique’s immune system to fight cancer. The enterprise is exploring a lot of compounds and immunotherapeutic procedures for patients with various kinds of cancer, together with learning the skills of mixing immuno-oncology agents that target different and complementary pathways in the medication of cancer.

    Bristol-Myers Squibb is dedicated to advancing the science of immuno-oncology, with the level of changing survival expectations and the manner sufferers are living with melanoma.

    concerning the Bristol-Myers Squibb and Ono Pharmaceutical Collaboration

    In 2011, via a collaboration agreement with Ono Pharmaceutical, Bristol-Myers Squibb expanded its territorial rights to develop and commercialize Opdivo globally apart from in Japan, South Korea and Taiwan, where Ono had retained total rights to the compound on the time. On July 23, 2014, Bristol-Myers Squibb and Ono Pharmaceutical extra improved the groups’ strategic collaboration agreement to jointly promote and commercialize several immunotherapies – as sole agents and composite regimens – for sufferers with melanoma in Japan, South Korea and Taiwan.

    important security assistance

    Immune-Mediated Pneumonitis

  • extreme pneumonitis or interstitial lung sickness, together with deadly circumstances, passed off with OPDIVO medication. throughout the medical trial adventure in 691 patients with strong tumors, deadly immune-mediated pneumonitis befell in 0.7% (5/691) of patients receiving OPDIVO; no circumstances happened in trial 1 or trial 3. In trial 1, pneumonitis, together with interstitial lung disorder, occurred in three.four% (9/268) of sufferers receiving OPDIVO and not one of the 102 sufferers receiving chemotherapy. Immune-mediated pneumonitis befell in 2.2% (6/268) of patients receiving OPDIVO; one with Grade three and 5 with Grade 2. In trial 3, immune-mediated pneumonitis took situation in 6% (7/117) of patients receiving OPDIVO, including, 5 Grade 3 and two Grade 2 situations. parade screen patients for signals and indicators of pneumonitis. Administer corticosteroids for Grade 2 or more suitable pneumonitis. permanently discontinue OPDIVO for Grade 3 or four and withhold OPDIVO until determination for Grade 2.
  • Immune-Mediated Colitis

  • In trial 1, diarrhea or colitis passed off in 21% (fifty seven/268) of sufferers receiving OPDIVO and 18% (18/102) of sufferers receiving chemotherapy. Immune-mediated colitis occurred in 2.2% (6/268) of patients receiving OPDIVO; five with Grade 3 and one with Grade 2. In trial three, diarrhea passed off in 21% (24/117) of patients receiving OPDIVO. Grade three immune-mediated colitis happened in 0.9% (1/117) of sufferers. monitor patients for immune-mediated colitis. Administer corticosteroids for Grade 2 (of more than 5 days length), 3, or 4 colitis. Withhold OPDIVO for Grade 2 or 3. completely discontinue OPDIVO for Grade 4 colitis or recurrent colitis upon restarting OPDIVO.
  • Immune-Mediated Hepatitis

  • In trial 1, there became an accelerated incidence of liver check abnormalities within the OPDIVO-treated group as compared to the chemotherapy-handled group, with increases in AST (28% vs 12%), alkaline phosphatase (22% vs 13%), ALT (sixteen% vs 5%), and complete bilirubin (9% vs 0). Immune-mediated hepatitis happened in 1.1% (three/268) of sufferers receiving OPDIVO; two with Grade three and one with Grade 2. In trial three, the incidences of elevated liver check values had been AST (16%), alkaline phosphatase (14%), ALT (12%), and complete bilirubin (2.7%). parade screen sufferers for abnormal liver exams earlier than and periodically total through treatment. Administer corticosteroids for Grade 2 or better transaminase elevations. Withhold OPDIVO for Grade 2 and permanently discontinue OPDIVO for Grade three or 4 immune-mediated hepatitis.
  • Immune-Mediated Nephritis and Renal Dysfunction

  • In trial 1, there become an improved incidence of increased creatinine within the OPDIVO-treated community as compared to the chemotherapy-handled group (13% vs 9%). Grade 2 or 3 immune-mediated nephritis or renal dysfunction came about in 0.7% (2/268) of patients. In trial three, the incidence of multiplied creatinine became 22%. Immune-mediated renal dysfunction (Grade 2) took situation in 0.9% (1/117) of sufferers. computer screen patients for expanded serum creatinine just before and periodically total over medication. For Grade 2 or three serum creatinine elevation, withhold OPDIVO and administer corticosteroids; if worsening or no improvement occurs, completely discontinue OPDIVO. Administer corticosteroids for Grade four serum creatinine elevation and permanently discontinue OPDIVO.
  • Immune-Mediated Hypothyroidism and Hyperthyroidism

  • In trial 1, Grade 1 or 2 hypothyroidism happened in eight% (21/268) of sufferers receiving OPDIVO and not one of the 102 patients receiving chemotherapy. Grade 1 or 2 hyperthyroidism befell in three% (eight/268) of patients receiving OPDIVO and 1% (1/102) of patients receiving chemotherapy. In trial 3, hypothyroidism happened in four.3% (5/117) of patients receiving OPDIVO. Hyperthyroidism occurred in 1.7% (2/117) of patients, including one Grade 2 case. video parade thyroid characteristic previous to and periodically during medication. Administer hormone replacement therapy for hypothyroidism. initiate scientific management for manage of hyperthyroidism.
  • other Immune-Mediated adversarial Reactions

  • In trial 1 and three (n=385), here clinically giant immune-mediated antagonistic reactions passed off in <2% of OPDIVO-handled sufferers: adrenal insufficiency, uveitis, pancreatitis, facial and abducens nerve paresis, demyeliniation, autoimmune neuropathy, motor dysfunction, and vasculitis. throughout medical trials of OPDIVO administered at doses 3 mg/kg and 10 mg/kg, additional clinically large, immune-mediated antagonistic reactions absorb been recognized: hypophysitis, diabetic ketoacidosis, hypopituitarism, Guillain-Barré syndrome, and myasthenic syndrome. based on the severity of adversarial reaction, withhold OPDIVO, administer high-dose corticosteroids, and, if acceptable, initiate hormone- alternative remedy.
  • Embryofetal Toxicity

  • according to its mechanism of action, OPDIVO may occasions fetal wound when administered to a pregnant lady. hint pregnant women of the skills chance to a fetus. hint women of reproductive skills to construct utilize of profitable contraception total through remedy with OPDIVO and for as a minimum 5 months after the ultimate dose of OPDIVO.
  • Lactation

  • It is not accepted whether OPDIVO is latest in human milk. because many medicine, including antibodies, are excreted in human milk and since of the potential for austere adverse reactions in nursing toddlers from OPDIVO, recommend ladies to discontinue breastfeeding total through medication.
  • critical hostile Reactions

  • In trial 1, sedate antagonistic reactions passed off in 41% of sufferers receiving OPDIVO. Grade three and four adversarial reactions passed off in forty two% of patients receiving OPDIVO. essentially the most everyday Grade 3 and four adverse drug reactions mentioned in 2% to <5% of sufferers receiving OPDIVO absorb been stomach pain, hyponatremia, elevated aspartate aminotransferase, and accelerated lipase.
  • In trial 3, sedate hostile reactions came about in fifty nine% of sufferers receiving OPDIVO. the most well-known austere hostile drug reactions suggested in ≥2% of patients had been dyspnea, pneumonia, habitual obstructive pulmonary disorder exacerbation, pneumonitis, hypercalcemia, pleural effusion, hemoptysis, and ache.
  • usual antagonistic Reactions

  • essentially the most common adverse reactions (≥20%) said with OPDIVO in trial 1 were rash (21%) and in trial 3 had been fatigue (50%), dyspnea (38%), musculoskeletal ache (36%), decreased appetite (35%), cough (32%), nausea (29%), and constipation (24%).
  • Please behold US plenary Prescribing guidance for OPDIVO.

    About Bristol-Myers Squibb

    Bristol-Myers Squibb is a global pharmaceutical industry whose mission is to find, boost and deliver creative drug treatments that uphold patients breathe triumphant over captious illnesses. For greater guidance about Bristol-Myers Squibb, visit, or commemorate us on Twitter at

    Bristol-Myers Squibb forward-searching statement

    This press release contains "ahead-searching statements" as that time epoch is defined in the private Securities Litigation Reform Act of 1995 concerning the analysis, construction and commercialization of pharmaceutical items. Such ahead-looking statements are according to existing expectations and involve inherent risks and uncertainties, including components that could delay, divert or change any of them, and could occasions specific results and outcomes to vary materially from existing expectations. No ahead-looking remark will besides breathe guaranteed. among different dangers, there can breathe no breathe positive that Opdivo will acquire regulatory approval within the European Union or, if authorised, that it is going to become a commercially a hit product. forward-searching statements during this press release should breathe evaluated along with the numerous uncertainties that impress Bristol-Myers Squibb's business, especially those recognized in the cautionary elements discussion in Bristol-Myers Squibb's Annual report on configuration 10-ok for the 12 months ended December 31, 2014 in their Quarterly studies on configuration 10-Q and their latest experiences on configuration eight-ok. Bristol-Myers Squibb undertakes no duty to publicly replace any ahead-searching commentary, whether on account of current assistance, future events or in any other case.

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    ECDL [1 Certification Exam(s) ]
    EMC [127 Certification Exam(s) ]
    Enterasys [13 Certification Exam(s) ]
    Ericsson [5 Certification Exam(s) ]
    Esri [2 Certification Exam(s) ]
    ExamExpress [15 Certification Exam(s) ]
    Exin [40 Certification Exam(s) ]
    ExtremeNetworks [3 Certification Exam(s) ]
    F5-Networks [20 Certification Exam(s) ]
    FCTC [2 Certification Exam(s) ]
    Filemaker [9 Certification Exam(s) ]
    Financial [36 Certification Exam(s) ]
    Fortinet [12 Certification Exam(s) ]
    Foundry [6 Certification Exam(s) ]
    Fujitsu [2 Certification Exam(s) ]
    GAQM [8 Certification Exam(s) ]
    Genesys [4 Certification Exam(s) ]
    GIAC [15 Certification Exam(s) ]
    Google [4 Certification Exam(s) ]
    GuidanceSoftware [2 Certification Exam(s) ]
    H3C [1 Certification Exam(s) ]
    HDI [9 Certification Exam(s) ]
    Healthcare [3 Certification Exam(s) ]
    HIPAA [2 Certification Exam(s) ]
    Hitachi [28 Certification Exam(s) ]
    Hortonworks [4 Certification Exam(s) ]
    Hospitality [2 Certification Exam(s) ]
    HP [744 Certification Exam(s) ]
    HR [2 Certification Exam(s) ]
    HRCI [1 Certification Exam(s) ]
    Huawei [21 Certification Exam(s) ]
    Hyperion [10 Certification Exam(s) ]
    IAAP [1 Certification Exam(s) ]
    IBM [1520 Certification Exam(s) ]
    IBQH [1 Certification Exam(s) ]
    ICAI [1 Certification Exam(s) ]
    ICDL [6 Certification Exam(s) ]
    IEEE [1 Certification Exam(s) ]
    IELTS [1 Certification Exam(s) ]
    IFPUG [1 Certification Exam(s) ]
    IIA [3 Certification Exam(s) ]
    IIBA [2 Certification Exam(s) ]
    IISFA [1 Certification Exam(s) ]
    Intel [2 Certification Exam(s) ]
    IQN [1 Certification Exam(s) ]
    IRS [1 Certification Exam(s) ]
    ISA [1 Certification Exam(s) ]
    ISACA [4 Certification Exam(s) ]
    ISC2 [6 Certification Exam(s) ]
    ISEB [24 Certification Exam(s) ]
    Isilon [4 Certification Exam(s) ]
    ISM [6 Certification Exam(s) ]
    iSQI [7 Certification Exam(s) ]
    ITEC [1 Certification Exam(s) ]
    Juniper [63 Certification Exam(s) ]
    Legato [5 Certification Exam(s) ]
    Liferay [1 Certification Exam(s) ]
    Lotus [66 Certification Exam(s) ]
    LPI [23 Certification Exam(s) ]
    LSI [3 Certification Exam(s) ]
    Magento [3 Certification Exam(s) ]
    Maintenance [2 Certification Exam(s) ]
    McAfee [8 Certification Exam(s) ]
    McData [3 Certification Exam(s) ]
    Medical [25 Certification Exam(s) ]
    Microsoft [362 Certification Exam(s) ]
    Mile2 [2 Certification Exam(s) ]
    Military [1 Certification Exam(s) ]
    Misc [1 Certification Exam(s) ]
    Motorola [7 Certification Exam(s) ]
    mySQL [4 Certification Exam(s) ]
    NCLEX [2 Certification Exam(s) ]
    Network-General [12 Certification Exam(s) ]
    NetworkAppliance [36 Certification Exam(s) ]
    NI [1 Certification Exam(s) ]
    NIELIT [1 Certification Exam(s) ]
    Nokia [6 Certification Exam(s) ]
    Nortel [130 Certification Exam(s) ]
    Novell [37 Certification Exam(s) ]
    OMG [10 Certification Exam(s) ]
    Oracle [262 Certification Exam(s) ]
    P&C [1 Certification Exam(s) ]
    Palo-Alto [4 Certification Exam(s) ]
    PARCC [1 Certification Exam(s) ]
    PayPal [1 Certification Exam(s) ]
    Pegasystems [11 Certification Exam(s) ]
    PEOPLECERT [4 Certification Exam(s) ]
    PMI [15 Certification Exam(s) ]
    Polycom [2 Certification Exam(s) ]
    PostgreSQL-CE [1 Certification Exam(s) ]
    Prince2 [6 Certification Exam(s) ]
    PRMIA [1 Certification Exam(s) ]
    PsychCorp [1 Certification Exam(s) ]
    PTCB [2 Certification Exam(s) ]
    QAI [1 Certification Exam(s) ]
    QlikView [1 Certification Exam(s) ]
    Quality-Assurance [7 Certification Exam(s) ]
    RACC [1 Certification Exam(s) ]
    Real-Estate [1 Certification Exam(s) ]
    RedHat [8 Certification Exam(s) ]
    RES [5 Certification Exam(s) ]
    Riverbed [8 Certification Exam(s) ]
    RSA [15 Certification Exam(s) ]
    Sair [8 Certification Exam(s) ]
    Salesforce [5 Certification Exam(s) ]
    SANS [1 Certification Exam(s) ]
    SAP [98 Certification Exam(s) ]
    SASInstitute [15 Certification Exam(s) ]
    SAT [1 Certification Exam(s) ]
    SCO [10 Certification Exam(s) ]
    SCP [6 Certification Exam(s) ]
    SDI [3 Certification Exam(s) ]
    See-Beyond [1 Certification Exam(s) ]
    Siemens [1 Certification Exam(s) ]
    Snia [7 Certification Exam(s) ]
    SOA [15 Certification Exam(s) ]
    Social-Work-Board [1 Certification Exam(s) ]
    SpringSource [1 Certification Exam(s) ]
    SUN [63 Certification Exam(s) ]
    SUSE [1 Certification Exam(s) ]
    Sybase [17 Certification Exam(s) ]
    Symantec [133 Certification Exam(s) ]
    Teacher-Certification [4 Certification Exam(s) ]
    The-Open-Group [8 Certification Exam(s) ]
    TIA [3 Certification Exam(s) ]
    Tibco [18 Certification Exam(s) ]
    Trend [1 Certification Exam(s) ]
    TruSecure [1 Certification Exam(s) ]
    USMLE [1 Certification Exam(s) ]
    VCE [6 Certification Exam(s) ]
    Veeam [2 Certification Exam(s) ]
    Veritas [32 Certification Exam(s) ]
    Vmware [57 Certification Exam(s) ]
    Wonderlic [1 Certification Exam(s) ]
    Worldatwork [2 Certification Exam(s) ]
    XML-Master [3 Certification Exam(s) ]
    Zend [6 Certification Exam(s) ]

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