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Immunotherapy Advances SCLC medicine panorama | killexams.com actual Questions and Pass4sure dumps

Christine Lee Hann, MD, PhD

Christine Lee Hann, MD, PhD

the unique ordinary of occupy keeping of the frontline medication of patients with wide-stage diminutive telephone lung melanoma (SCLC) should live atezolizumab (Tecentriq) and chemotherapy, according to consequences from the IMpower133 trial, notable Christine Lee Hann, MD, PhD.

This world, randomized section III visitation validated an improvement in survival with the addition of the PD-L1 inhibitor to criterion carboplatin and etoposide in patients with huge-stage SCLC versus the chemotherapy routine alone.

After a median follow-up of 13.9 months, the median universal survival (OS) within the experimental arm changed into 12.3 months compared with 10.three months with chemotherapy lonely (HR, 0.70; 95% CI, 0.54-0.91; P = .0069). Median progression-free survival (PFS) changed into 5.2 months within the atezolizumab arm compared with 4.3 months in the placebo arm.

within the cohort of 403 remedy-naïve patients, impeccable sufferers obtained four 21-day cycles of carboplatin AUC 5 mg/mL/min intravenously (IV) on day 1 and a hundred mg/m2 etoposide IV on days 1 via three. sufferers were also randomized 1:1 to acquire both concurrent atezolizumab at 1200 mg IV on day 1 (n = 201) or placebo (n = 202) impeccable the course through the induction part. medication become followed with the aid of upkeep therapy with atezolizumab or placebo, in response to the outdated random assignment, every 3 weeks until progressive sickness or loss of clinical advantage.

in addition, single-agent nivolumab (Opdivo) was granted an accelerated FDA approval in August 2018 for the remedy of patients with SCLC with ailment development following platinum-based mostly chemotherapy and 1 different line of therapy, marking the first drug approval in this sickness in well-nigh 20 years.

youngsters, other immunotherapy suggestions haven't shown the equal exercise. as an instance, in the angle III CheckMate-451 trial, the combination of nivolumab and ipilimumab (Yervoy) did not enrich OS versus placebo as a protection remedy for patients with wide-stage SCLC with out ailment development following frontline platinum-based chemotherapy.

In an interview impeccable the course through the 2018 OncLive® on the 2018 status of the Science Summit™ on superior Non–Small phone Lung cancer, Hann, an associate professor of Oncology at Johns Hopkins college of medication, discussed how recent information hold fashioned SCLC remedy.

OncLive: What are the recent advances in SCLC remedy? Hann: probably the most most exciting fresh information emerged at the nineteenth World conference on Lung cancer. Stephen V. Liu, MD, offered outcomes from the IMpower133 examine which evaluated first-line chemotherapy in combination with the PD-L1 inhibitor atezolizumab. This turned into the first study in the frontline setting to exhibit better survival benefit; in fact, there was development in PFS and OS in sufferers who obtained the combination. They deem this can now live considered the unique medium of occupy keeping of frontline medicine of this affected person inhabitants. How Do you behold researchers compounding this statistics for future development? there is a mighty deal to search for forward to. within the eventual couple of years, we've had an gigantic emergence of records both on the organic finish and on the clinical facet. They maintain in intuition the disease improved and we've discovered unique agents, reminiscent of checkpoint inhibitors, which hold efficacy during this space. The checkpoint inhibitors were efficient in the second-line atmosphere and past.

really, nivolumab bought FDA approval in August 2018 in the third-line setting of SCLC; this turned into the first drug approval they had in 2 many years and it turned into an incredible accomplishment in the box. They are actually combinations and unique molecular targets during this area.

What are some of those rising molecular pursuits and targeted treatments? there has been a renewed pastime in gaining erudition of SCLC. Consequentially, there has been improved funding from the national melanoma Institute to assist us maintain in intuition the sickness more advantageous. [This renewed interest in SCLC] has emerged in parallel with technological advances that enable us to obtain a abysmal genomic understanding. They are actually in a position to net epigenetic and proteomic profiles of the melanoma. within the remaining 5 years, there has been increasing assistance on the proteins expressed in SCLC that may well live pursuits.

It is going to occupy a very long time to in reality tease through impeccable these details, however we're relocating in the revise course. SCLC is a melanoma with a very tall tumor mutation burden, so there is doubtless a chore for combined focused remedies.

what's a closing unmet want in SCLC? There had been only a few studies taking a search for at restrained-stage SCLC. whereas there is healing capabilities with chemotherapy and radiation, the substantial majority of sufferers recur locally and distantly. There are reports with immune-checkpoint inhibitors underway in this area, and people [data] could live very constructive. With the encouraging information they saw with durvalumab (Imfinzi) in stage III non–small cell lung melanoma, they deem there is fantastic competencies for previous-line immunotherapy. what's your take-home message to neighborhood oncologists? we hold a unique common of keeping for first-line medication of SCLC. numerous reports will also live study out within the subsequent yr or so in an ail to expand their armamentarium even further. they are able to behold statistics mien on the exhaust of checkpoint inhibitors within the upkeep atmosphere, no matter if [they are being used] in aggregate or as lone agents. long-term biomarker studies are also standard.

Liu S, Mansfield A, Szczesna S, et al. First-line atezolizumab plus chemotherapy in extensive-stage small-cell lung melanoma [published online September 25, 2018]. N Eng J Med. doi: 10.1056/NEJMoa1809064.


Celldex: What's the entire exhilaration About? | killexams.com actual Questions and Pass4sure dumps

No outcomes discovered, are attempting unique keyword!CDX-1127 is an antibody that raises T phone exercise that however a bit differentiated in mechanism of action can live compared to the checkpoint inhibitors Yervoy ... had revenue on $1.1 billion in ...

Bristol-Myers Squibb Receives tremendous CHMP feeling within the European Union for Opdivo (nivolumab) for the medicine of superior Melanoma in each First-Line and up to now ... | killexams.com actual Questions and Pass4sure dumps

PRINCETON, N.J.--(business WIRE)--Bristol-Myers Squibb commerce (NYSE:BMY) nowadays announced that the Committee for Medicinal items for Human exhaust (CHMP) of the european drugs company (EMA) has adopted a conducive feeling recommending that Opdivo (nivolumab), a PD-1 immune checkpoint inhibitor, live granted popularity of exhaust in both first-line and in the past handled sufferers with advanced (unresectable or metastatic) melanoma. here is the primary high-quality feeling given by course of the CHMP for a PD-1 immune checkpoint inhibitor, and it will now live reviewed by the eu fee, which has the authority to approve drugs for the eu Union (ecu).

The EMA granted Bristol-Myers Squibb accelerated evaluation of Opdivo in response to current laws that fulfills its suggestions about “medicinal items of foremost interest from the factor of view of public health and in selected from the view aspect of therapeutic innovation.”

“we are completely satisfied with today’s CHMP fine opinion, as it is a step closer to us bringing this faultfinding drugs for these advanced melanoma sufferers in Europe in want of recent alternate options,” spoke of Michael Giordano, senior vp, Head of construction, Oncology. “Our vision is to seriously change how they manner melanoma – from scientific exercise to greater patient consequences. They continue to expand the breadth and depth of their immuno-oncology portfolio throughout the continuum of melanoma and assorted other cancers, to provide extra sufferers with the talents possibility for long-time epoch survival.”

wonderful feeling according to CheckMate -066, -037

The CHMP wonderful feeling is in line with facts from two fraction III studies (CheckMate -066 and -037), demonstrating the efficacy and security of Opdivo in advanced melanoma sufferers with vital unmet wants. CheckMate -066, a fraction III randomized double-blind examine, evaluating Opdivo to the chemotherapy dacarbazine (DTIC) in sufferers with medication-naïve advanced melanoma, is the primary angle III visitation of an investigational PD-1 immune checkpoint inhibitor to present an timehonored survival edge in advanced melanoma, as well as a stronger purpose response rate. A 2d study, CheckMate -037, is a angle III randomized, controlled open-label study of Opdivo versus investigator’s alternative chemotherapy in sufferers with advanced melanoma who were up to now handled with Yervoy (ipilimumab), which confirmed development in point response rates. These records are supported by means of a angle Ib search for at (study -003) in relapsed superior or metastatic melanoma, which validated the first characterization of Opdivo advantage/chance in advanced melanoma. There was consistent Opdivo dosing of 3 mg/kg every two weeks throughout impeccable three trials.

About Opdivo

Bristol-Myers Squibb has a huge, global development program to analyze Opdivo in assorted tumor forms along with more than 50 trials – as monotherapy or in amalgam with other treatments – in which more than 7,000 patients had been enrolled worldwide.

Opdivo became the primary PD-1 immune checkpoint inhibitor to net hold of regulatory approval anyplace on this planet on July four, 2014 when Ono Pharmaceutical Co. announced that it acquired manufacturing and advertising approval in Japan for the medicine of patients with unresectable melanoma. within the U.S., the U.S. meals and Drug Administration (FDA) granted its first approval for Opdivo for the remedy of patients with unresectable or metastatic melanoma and disorder development following Yervoy (ipilimumab) and, if BRAF V600 mutation effective, a BRAF inhibitor. On March 5, 2015, Opdivo recently received its second FDA approval for the treatment of patients with metastatic squamous non-small mobile lung melanoma (NSCLC) with progression on or after platinum-based mostly chemotherapy.

About superior Melanoma

Melanoma is a kindly of skin cancer characterized via the uncontrolled boom of pigment-producing cells (melanocytes) observed in the skin. Metastatic melanoma is the deadliest profile of the disorder, and happens when melanoma spreads beyond the surface of the dermis to the other organs, such because the lymph nodes, lungs, brain or other areas of the physique. The incidence of melanoma has been increasing for as a minimum 30 years. In 2012, an estimated 232,a hundred thirty melanoma circumstances had been diagnosed globally. Melanoma is in generic curable when handled in its early ranges. youngsters, in its late stages, the ordinary survival fee has traditionally been simply six months with a one-yr mortality expense of 75%, making it one of the crucial aggressive types of cancer.

Immuno-Oncology at Bristol-Myers Squibb

surgical procedure, radiation, cytotoxic or targeted healing procedures hold represented the mainstay of cancer treatment over the remaining several decades, however lengthy-term survival and a conducive first-class of lifestyles hold remained elusive for a lot of sufferers with advanced disease.

To exploit this unmet scientific need, Bristol-Myers Squibb is main analysis in an innovative box of cancer analysis and medication called immuno-oncology, which includes agents whose primary mechanism is to travail without detain with the body’s immune system to combat cancer. The enterprise is exploring loads of compounds and immunotherapeutic methods for sufferers with several types of melanoma, including learning the potential of mixing immuno-oncology agents that target different and complementary pathways in the remedy of cancer.

Bristol-Myers Squibb is committed to advancing the science of immuno-oncology, with the purpose of changing survival expectations and the course patients are vital with cancer.

about the Bristol-Myers Squibb and Ono Pharmaceutical Collaboration

In 2011, via a collaboration condense with Ono Pharmaceutical, Bristol-Myers Squibb improved its territorial rights to boost and commercialize Opdivo globally apart from in Japan, South Korea and Taiwan, where Ono had retained impeccable rights to the compound on the time. On July 23, 2014, Bristol-Myers Squibb and Ono Pharmaceutical additional extended the corporations’ strategic collaboration agreement to jointly boost and commercialize distinctive immunotherapies – as lone agents and amalgam regimens – for sufferers with melanoma in Japan, South Korea and Taiwan.

vital safety suggestions

Immune-Mediated Pneumonitis

  • extreme pneumonitis or interstitial lung disease, including deadly situations, occurred with OPDIVO medication. across the clinical visitation sustain in 691 patients with solid tumors, deadly immune-mediated pneumonitis happened in 0.7% (5/691) of patients receiving OPDIVO; no cases happened in visitation 1 or visitation three. In visitation 1, pneumonitis, including interstitial lung disorder, befell in 3.4% (9/268) of sufferers receiving OPDIVO and not one of the 102 patients receiving chemotherapy. Immune-mediated pneumonitis came about in 2.2% (6/268) of patients receiving OPDIVO; one with Grade 3 and 5 with Grade 2. In visitation three, immune-mediated pneumonitis came about in 6% (7/117) of sufferers receiving OPDIVO, including, 5 Grade 3 and two Grade 2 cases. monitor sufferers for indications and signs of pneumonitis. Administer corticosteroids for Grade 2 or greater pneumonitis. completely discontinue OPDIVO for Grade 3 or 4 and withhold OPDIVO unless determination for Grade 2.
  • Immune-Mediated Colitis

  • In visitation 1, diarrhea or colitis passed off in 21% (57/268) of patients receiving OPDIVO and 18% (18/102) of sufferers receiving chemotherapy. Immune-mediated colitis occurred in 2.2% (6/268) of sufferers receiving OPDIVO; 5 with Grade 3 and one with Grade 2. In visitation 3, diarrhea took status in 21% (24/117) of sufferers receiving OPDIVO. Grade 3 immune-mediated colitis occurred in 0.9% (1/117) of sufferers. display screen patients for immune-mediated colitis. Administer corticosteroids for Grade 2 (of greater than 5 days period), three, or 4 colitis. Withhold OPDIVO for Grade 2 or three. completely discontinue OPDIVO for Grade 4 colitis or recurrent colitis upon restarting OPDIVO.
  • Immune-Mediated Hepatitis

  • In visitation 1, there become an accelerated incidence of liver test abnormalities in the OPDIVO-treated group as compared to the chemotherapy-treated group, with increases in AST (28% vs 12%), alkaline phosphatase (22% vs 13%), ALT (sixteen% vs 5%), and complete bilirubin (9% vs 0). Immune-mediated hepatitis took status in 1.1% (3/268) of patients receiving OPDIVO; two with Grade three and one with Grade 2. In visitation three, the incidences of extended liver check values had been AST (16%), alkaline phosphatase (14%), ALT (12%), and complete bilirubin (2.7%). computer screen patients for abnormal liver checks earlier than and periodically impeccable over treatment. Administer corticosteroids for Grade 2 or enhanced transaminase elevations. Withhold OPDIVO for Grade 2 and completely discontinue OPDIVO for Grade 3 or four immune-mediated hepatitis.
  • Immune-Mediated Nephritis and Renal Dysfunction

  • In visitation 1, there turned into an improved incidence of expanded creatinine in the OPDIVO-handled neighborhood as compared to the chemotherapy-treated group (13% vs 9%). Grade 2 or three immune-mediated nephritis or renal dysfunction came about in 0.7% (2/268) of patients. In visitation 3, the incidence of multiplied creatinine turned into 22%. Immune-mediated renal dysfunction (Grade 2) befell in 0.9% (1/117) of sufferers. video display sufferers for increased serum creatinine just before and periodically impeccable over treatment. For Grade 2 or three serum creatinine elevation, withhold OPDIVO and administer corticosteroids; if worsening or no growth happens, permanently discontinue OPDIVO. Administer corticosteroids for Grade four serum creatinine elevation and completely discontinue OPDIVO.
  • Immune-Mediated Hypothyroidism and Hyperthyroidism

  • In visitation 1, Grade 1 or 2 hypothyroidism took status in eight% (21/268) of patients receiving OPDIVO and zilch of the 102 patients receiving chemotherapy. Grade 1 or 2 hyperthyroidism occurred in three% (8/268) of patients receiving OPDIVO and 1% (1/102) of patients receiving chemotherapy. In visitation three, hypothyroidism passed off in four.3% (5/117) of patients receiving OPDIVO. Hyperthyroidism occurred in 1.7% (2/117) of sufferers, including one Grade 2 case. display screen thyroid duty prior to and periodically impeccable through remedy. Administer hormone substitute therapy for hypothyroidism. initiate medical administration for control of hyperthyroidism.
  • other Immune-Mediated hostile Reactions

  • In visitation 1 and three (n=385), privilege here clinically colossal immune-mediated antagonistic reactions occurred in <2% of OPDIVO-treated patients: adrenal insufficiency, uveitis, pancreatitis, facial and abducens nerve paresis, demyeliniation, autoimmune neuropathy, motor dysfunction, and vasculitis. across scientific trials of OPDIVO administered at doses three mg/kg and 10 mg/kg, extra clinically huge, immune-mediated hostile reactions hold been recognized: hypophysitis, diabetic ketoacidosis, hypopituitarism, Guillain-Barré syndrome, and myasthenic syndrome. based on the severity of adverse reaction, withhold OPDIVO, administer excessive-dose corticosteroids, and, if appropriate, stir hormone- substitute therapy.
  • Embryofetal Toxicity

  • in accordance with its mechanism of action, OPDIVO may intuition fetal harm when administered to a pregnant lady. recommend pregnant women of the erudition risk to a fetus. advise ladies of reproductive skills to sequel exhaust of valuable contraception impeccable over medication with OPDIVO and for at least 5 months after the ultimate dose of OPDIVO.
  • Lactation

  • It is not established even if OPDIVO is present in human milk. as a result of many medicine, together with antibodies, are excreted in human milk and because of the abilities for faultfinding opposed reactions in nursing toddlers from OPDIVO, advise girls to discontinue breastfeeding throughout medicine.
  • severe opposed Reactions

  • In visitation 1, faultfinding hostile reactions occurred in forty one% of patients receiving OPDIVO. Grade three and 4 opposed reactions came about in forty two% of patients receiving OPDIVO. probably the most usual Grade 3 and four opposed drug reactions pronounced in 2% to <5% of patients receiving OPDIVO hold been abdominal pain, hyponatremia, multiplied aspartate aminotransferase, and increased lipase.
  • In visitation three, austere adversarial reactions occurred in 59% of sufferers receiving OPDIVO. the most regularly occurring faultfinding adverse drug reactions pronounced in ≥2% of sufferers were dyspnea, pneumonia, persistent obstructive pulmonary sickness exacerbation, pneumonitis, hypercalcemia, pleural effusion, hemoptysis, and pain.
  • usual adversarial Reactions

  • essentially the most commonplace adverse reactions (≥20%) mentioned with OPDIVO in visitation 1 had been rash (21%) and in visitation three hold been fatigue (50%), dyspnea (38%), musculoskeletal ache (36%), lowered appetite (35%), cough (32%), nausea (29%), and constipation (24%).
  • Please behold US plenary Prescribing guidance for OPDIVO.

    About Bristol-Myers Squibb

    Bristol-Myers Squibb is a global pharmaceutical company whose mission is to find, enhance and carry innovative drugs that aid patients live triumphant over faultfinding ailments. For more recommendation about Bristol-Myers Squibb, search recommendation from www.bms.com, or comply with us on Twitter at http://twitter.com/bmsnews.

    Bristol-Myers Squibb ahead-looking statement

    This press free up consists of "forward-searching statements" as that term is described within the inner most Securities Litigation Reform Act of 1995 concerning the research, construction and commercialization of pharmaceutical items. Such ahead-looking statements are in keeping with present expectations and hold inherent risks and uncertainties, including components that might delay, divert or change any of them, and will trigger actual results and results to vary materially from existing expectations. No forward-looking commentary may also live guaranteed. amongst other risks, there can also live no guarantee that Opdivo will acquire regulatory approval in the European Union or, if accredited, that it will become a commercially a success product. forward-searching statements during this press free up should live evaluated along side the various uncertainties that impress Bristol-Myers Squibb's business, mainly these identified in the cautionary elements discussion in Bristol-Myers Squibb's Annual document on kindly 10-okay for the 12 months ended December 31, 2014 in their Quarterly stories on profile 10-Q and their existing reports on kindly 8-okay. Bristol-Myers Squibb undertakes no duty to publicly update any ahead-searching commentary, whether on account of unique advice, future events or otherwise.


    156-915-1 Accelerated CCSE 1.1 NGX

    Study guide Prepared by Killexams.com CheckPoint Dumps Experts


    Killexams.com 156-915-1 Dumps and actual Questions

    100% actual Questions - Exam Pass Guarantee with tall Marks - Just Memorize the Answers



    156-915-1 exam Dumps Source : Accelerated CCSE 1.1 NGX

    Test Code : 156-915-1
    Test denomination : Accelerated CCSE 1.1 NGX
    Vendor denomination : CheckPoint
    practice test : 272 actual Questions

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    With unique Turing, NVIDIA Doubles Down on the Future of Real-Time Ray-Tracing | killexams.com actual questions and Pass4sure dumps

    18 Oct, 2018 By: Alex Herrera Herrera on Hardware: CAD professionals are expected to gleam the benefits.

    NVIDIA's long-expected successor to its Pascal GPU architecture for gaming and professional graphics is here. In August, the GPU developer pulled the covers off Turing, which one could quarrel is both a successor to not one but both of its preceding generations of graphics processing units — 2016's Pascal and 2017's Volta. In the process, the company confirmed several of the more expected 3D graphics advancements for its next flagship GPU. But it also revealed a few surprises, representing an aggressive-but-justified departure from past generations' decisions about how it formulates products that today are destined for a far wider spectrum of applications than those of years past.

    Perhaps even more significant is the inflection point in GPU evolution that Turing marks, a unification — if not permanent and all-encompassing, at the very least meaningful — of the previous disparate and often conflicting priorities between the GPU's traditional 3D graphics markets and the passionate emerging opportunities attracting the company's attention. With Turing, NVIDIA confirms two realizations very much reflected in the GPU's DNA: one, that machine learning is now a telling and justified tool to enhance 3D visual computing; and two, that the time is ripe to originate the long-awaited transition from 3D raster graphics to the ultimate in rendering, real-time ray-tracing.

    Turing, RTX, and NGX

    NVIDIA is finding more ways to leverage machine learning to better performance and character for traditional 3D graphics. It's been a while since NVIDIA shaped unique GPU architectures and technology strictly for the profit of traditional raster-based 3D graphics that CAD applications and users hold primarily relied upon. Over the past decade, NVIDIA GPUs hold pushed well beyond that core space and into high-performance computation ("compute"), autonomous vehicles, robotics, supercomputing, and now, front-and-center, machine learning. And each unique generation has walked a mindful balance, supporting unique applications without handicapping the GPU for its bread-and-butter 3D graphics markets.

    With Turing, NVIDIA made many of the more conventional improvements to its fundamental 3D graphics programmable shader engine, the Streaming Multiprocessor (SM), especially in terms of faultfinding resources fancy chip registers and cache, and dialed up supporting infrastructure including external memory bandwidth — impeccable profitable things that contribute to faster, higher-quality interactive 3D graphics crucial to improving the CAD sustain and productivity. But those tweaks represent the more expected steps along the tried-and-true GPU evolution path, taking on cost and complexity for features and performance the company is pretty darn positive ISVs and finish users alike will value in the near term, if not immediately. More noteworthy than the more conventional 3D graphics features Turing added is what it didn't subtract from the company's previous compute/artificial intelligence (AI)–focused GPU, Volta. With Turing, NVIDIA architects not only didn't strip out Volta's Tensor Cores, they improved on them — and doubled down on the pursuit of real-time rendering by boosting ray-trace-specific acceleration.

    Tensor Cores accelerated AI for ray-tracing — and now they hasten conventional 3D raster graphics to boot. Volta's most noteworthy advancement was the inclusion of Tensor Cores, unique hardware engines — of significant incremental chip cost (i.e. transistors/silicon area) — to accelerate processing of abysmal neural networks (DNNs), the lifeblood of machine learning applications. Now, given Volta's primary focus on high-performance computing rather than 3D graphics, the preference to occupy on the silicon cost of Tensor Cores was certainly novel, but not particularly contentious.

    But unlike Volta and its compute focus, Turing is a graphics-first architecture, so NVIDIA's determination to maintain Tensor Cores in Turing raises a very pertinent question: Why would the company dedicate significant cost in a graphics-focused GPU to a feature that doesn't directly profit graphics? Well, the retort is most tantalizing and fortunate: That stale premise is no longer true, and NVIDIA is now finding compelling ways to leverage machine learning to better the character and performance of 3D imagery.

    As discussed in detail in a previous column, "What Does NVIDIA's Ray Tracing advice spell for the CAD Market?" NVIDIA figured out a course to leverage abysmal learning to significantly better the performance of ray-traced 3D rendering. Specifically, RTX software exploits Tensor Core hardware incorporated in a DNN in the ray-tracer to accelerate image "convergence" by decreasing the computational load in the latter stages of rendering. Once the image converges into something it can recognize, AI fills in remaining rays/pixels, intelligently de-noising the image and wrapping up the time-consuming rendering process far faster than is possible via exhaustive, full-resolution ray processing.

    RTX technology on Volta (right side) accelerates ray-tracing through machine learning. (Source: NVIDIA)RTX technology (right side) accelerates ray-tracing through AI-accelerated de-noising, compared with the very number of rays without de-noising (left).  (Source: NVIDIA)

    No doubt enthused by the successful synergy of machine learning and graphics with ray-trace processing, NVIDIA researchers began exploring other ways to extract more visual processing goodness out of its GPUs' AI prowess. Extending on the exhaust of DNNs for ray-trace de-noising, NVIDIA unveiled NGX technology, comprised of an expanded set of DNN-driven image-enhancement features.

    The most relevant and compelling specimen using Turing/NGX to enhance conventional 3D graphics is abysmal Learning Super Sampling (DLSS). Essentially, DLSS benefits from a Tensor Core–accelerated DNN that substitutes the usual brute-force pixel super-sampling with knowing choices based on the scene geometry, and based both on one frame instance and interframe temporal changes. The profit is that character improves at the very performance level, or likely more tantalizing for most applications (because resolution-dependent character is pretty darn profitable at this point), performance increases significantly at the very character level. I hold no doubt NVIDIA sees NGX today as anything but a fixed set of features, but rather an evolving and expanding toolbox of DNNs that can further harness machine learning for the profit of NVIDIA's traditional visual markets as time goes on.

    AI-enabled DLSS anti-aliasing: There’s  mighty value in any GPU feature that can deliver the  very  character in fewer cycles. (Source: NVIDIA)AI-enabled DLSS anti-aliasing: There's mighty value in any GPU feature that can deliver the very character in fewer cycles. (Source: NVIDIA)

    And NVIDIA Doubles Down with RT Cores

    Not only did NVIDIA preserve those Tensor Cores when creating Turing, it took the further step of adding multiple instances (one per SM) of an entirely unique core design: the RT Core. Specifically, the RT Core takes on a faultfinding ray-tracing computing task, one that when executing on previous GPUs' SMs proved cumbersome, inefficient, and time-intensive. Determining whether a ray (shot from a viewport out into the scene) actually intersects an kick (and which triangle on that object's surface) is one of those tasks that a traditional raster-based 3D shader wasn't designed to do, and therefore doesn't Do particularly well. With Turing, that job is now left to the RT Cores, freeing up the SMs to disburse cycles instead on the 3D shader processing they're more adept at executing.

    Turing’s Streaming Multiprocessor with RT Core. (Source: NVIDIA)Turing's Streaming Multiprocessor with RT Core. (Source: NVIDIA)

    What's the internal micro-architecture of the RT Core search for like? Well, NVIDIA hasn't exposed the guts, but given its chore — a lot of 3D geometry processing — there's exiguous doubt some high-performance vector and matrix floating-point units profile its foundation. What NVIDIA has disclosed is the performance of the RT Core: 10 GigaRays/second. Now, in absolute terms, that's a hard number to assess — fancy triangles/second in the rasterization world — as it impeccable depends on the workload of each ray measured. The more relevant, apples-to-apples comparison is that rate relative to Pascal's 1.1 GigaRays/second, presumably of the very workload per ray. Given that, Turing is packing a 10X performance improvement processing a crucial and demanding portion of the ray-tracing pipeline.

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    Intercontinental Exchange's (ICE) CEO Jeff Sprecher on Q4 2017 Results - Earnings convene Transcript | killexams.com actual questions and Pass4sure dumps

    No result found, try unique keyword!ICE’s consolidated fourth quarter net revenues increased 1% to $1.1 billion. Data revenues increased 2% as reported ... including the Bank of America/Merrill Lynch indices, Euroclear, NGX and BondPoin...


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